Investigation of the effect of Polygonum cognatum Meissn. ethanol extract Bax, Caspase-3, Bcl-2, NF-B and NRF-2/HO-1 pathways in streptozotocin induced diabetic rats

In this study, it was investigated of the effect Polygonum cognatum Meissn. ethanol extract Bax, Bcl-2, Caspase-3, NF-kB and NRF-2/HO-1 pathways in streptozotocin induced diabetic rats. A total 24 healthy Spraque-Dawley male rats were randomly divided into four groups containing 6 per group as Control; Diabetes mellitus (DM); (PCE) DM+PCE. Experimental diabetes by a single dose 60 mg/kg/i.p Streptozotocin (STZ) injection for DM DM+PCE groups. The animals showing (Blood glucose level >250 mg/dL) will be selected 7 th days. PCE given at 10 mg/kg /day/p.o via gavage 20 All sacrificed on day, taken blood dissected kidney tissues ender anesthesia. COX-2, HO-1, Nrf-2 expression levels determined western blotting tissue. Compared with control groups, COX-2 increased (p<0.001); HO-1 decreased group. STZ increased. treats STZ-induced injury regulating apoptosis parameters such inflammation as, NF-kB, against diabetes. It concluded that can used therapeutic agent after determining molecular processes behind benefits damage damage. According to biochemical findings, treatment Bax Caspase-3 pathways, protein when administered presented pioneering study literature.